HELP

On this page you will learn more about how to use DIDA and its website.

WHAT IS DIDA?
DIDA is a novel database of known digenic combinations involved in different human digenic diseases. It represents a first systematic effort in collecting information related to these diseases in a single repository. More information about digenic inheritance and the rationale behind DIDA can be found on the HOME page.

ACCESS AND DOWNLOAD THE DATA PRESENT IN DIDA.
Figure 1 represents the conceptual framework of DIDA. The basis of DIDA is a digenic combination, found in a patient that is affected with a digenic disease. Each digenic combiantion has a unique ID (“dd000”) and is composed of two, three or four variants present in two genes, that are both linked to a digenic disease.

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Figure 1: Conceptual framework of DIDA.

All information present in DIDA can be accessed through the BROWSE page. The data is provided to you under the form of four tables: GENES, VARIANTS, DIGENIC COMBINATIONS and DISEASES. These tables can be accessed by clicking on their names (see figure 2). An explanation about the content in each column of the four tables can be found by hovering over the column header or checking the DOCUMENTATION page.

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Figure 2: BROWSE page with four tables: GENES, VARIANTS, DIGENIC COMBINATIONS and DISEASES.

Figure 3 provides an overview of the functionalities present in the tables that can be accessed through the BROWSE page.

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Figure 3: Overview of the functionalities present in the tables on the BROWSE page.

Clicking on the ID of a digenic combination (“dd000”) opens an overview page with all the information present in DIDA regarding the combination-of-interest (figure 4). An overview of how this page looks is present in figure 5.

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Figure 4: Digenic combinations table with link to specific digenic combination page.

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Figure 5: structure of the specific page for each digenic combination.

A link to the original publication in which the digenic combinations are described can be found on the REFERENCES page. Figure 6 provides an overview of the functionalities present on this page.

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Figure 6: overview of the functionalities present in the REFERENCES table.


SUMBIT YOUR DATA.
Besides browsing through the existing data, we also allow users to send their information to expand the database. New submissions will only be accepted after careful manual inspection. Information on how and what to submit can be found on the SUBMIT page.

STATISTICS.
Some general statistics about the data present in DIDA are gathered on the STATISTICS page. Each graphical representation of the data is accompanied by a short explanation of what is shown.